Table 3.

Quantitative Pupil Characteristics Prior to First-Time NOA (218 patients, 3625 total observations)

A. Size difference (mm) prior to pupil observations	NOA (M=138) vs. No NOA (M=3487)
Diff Size	OR [95% CI]	p
One observation prior (N=191, M=3282)	10.34 [5.08, 20.80]	<0.001*
Two observations prior (N=167 M=2898)	6.99 [3.09, 15.45]	<0.001*
Three observations prior (N=146, M=2314)	6.04 [2.40, 14.77]	<0.001*
Four observations prior (N=123, M=1773)	13.27 [4.65, 36.95]	<0.001*
B. Minimum NPi prior to FT-NOA pupil observations	NOA-Abnormal (M=44) vs. NOA-Normal (M=94)
Min NPi	OR [95% CI]	p
One observation prior (N=107, M=107)	0.25 [0.12, 0.45]	<0.001*
Two observations prior (N=88, M=88)	0.26 [0.11, 0.47]	<0.001*
Three observations prior (N=69, M=69)	0.21 [0.07, 0.44]	<0.001*
Four observations prior (N=52, M=52)	0.24 [0.07, 0.53]	0.004*

Panel A reports univariate mixed effects logistic regression models to account for inter-subject variability testing first-time NOA and size difference up to four observations prior. Panel B reports univariate logistic regression for first-time NOA phenotype and minimum NPi. All models adjust for GCS and osmotic medications prior to observation. Abbreviations: OR = Odds Ratio, CI = Confidence Interval, NOA = New Onset Anisocoria, FT-NOA = First-Time NOA, N=patients, M=observations. Observational sample sizes are included in Supplementary Methods.