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. 2022 Feb 2;7:13. doi: 10.1038/s41536-022-00208-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a i.p. MTX, p.a. MBV, and i.v. MBV decrease the ratio of splenic pro-inflammatory, M1-like macrophages (CD68+/CD86+/CD206−) to anti-inflammatory, M2-like macrophages (CD68+/CD86−/CD206+) compared to Pristane + PBS (p < 0.05). b UMAP dimensional reduction of the entire splenic myeloid compartment revealed an M2-predominant cluster as outlined in rectangular outline that is unique to MBV treatment. c The M2-predominant cluster unique to MBV treatment is driven by immunoregulatory, CD43hi/His48lo/CD206+ circulating monocytes in the spleen. All values in panels a represent mean ± s.e.m. (n = 4). UMAP plots in b and c represent concatenated values of four biological replicates.