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. 2021 Sep 1;126(3):482–491. doi: 10.1038/s41416-021-01538-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Linear regression standard dilution curves for WGS-MRD markers detected by quantitative RT-PCR in a ALL, b HR-NB and c EWS. Slope and R² values are shown in Table 2. C_t values represent the mean of triplicate experiments and are plotted against sample serial dilution based on the lowest quantitative range of 10⁻⁴ (0.01%) or 10⁻⁵ (0.001). d Pearson’s correlation analysis of patient-specific CDKN2A/B MRD assays to previously developed Ig/TCR assays using qPCR in clinical samples from six ALL patients. Each data point represents an individual clinical sample. Dotted lines indicate thresholds for positive, but non-quantitative (PNQ) MRD as assigned according to EuroMRD guidelines.