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. 2022 Feb 2;13:620. doi: 10.1038/s41467-022-28251-6

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Representative images of NRVM monolayers transduced with h2SheP-T2A-GFP lentiviruses driven under cTnT (a), CMV (b), or MHCK7 (c) promoter. d Relative mRNA expression of the h2SheP gene normalized to housekeeping gene B2M, quantified in NRVMs transduced with specified lentiviruses (n = 5 for cTnT-h2SheP group, n = 10 for CMV- and MHCK7-h2SheP groups). *P = 0.0346, CMV-h2SheP vs. cTnT-h2SheP; *P = 0.0103, MHCK7-h2SheP vs. cTnT-h2SheP. e–g Average conduction velocity (e, CV), APD80 (f), and maximum capture rate (g, MCR) values determined during optically mapped AP propagation in NRVM monolayers transduced with a CMV-GFP lentivirus (Control) or specified h2SheP lentiviruses (n = 6). *P = 0.0155, MHCK7-h2SheP vs. cTnT-h2SheP; ***P = 0.0003, CMV-h2SheP vs. Control; ****P < 0.0001, MHCK7-h2SheP vs. Control in e. Error bars indicate s.e.m; statistical significance was determined by one-way ANOVA, followed by Tukey’s post-hoc test to calculate P-values. Source data are provided as a Source Data file.