Table 3.
GO enrichment analysis of DEGs emerged from the comparison between “BM” vs “ES” CTCs.
| Term | Description | Genes | P value |
|---|---|---|---|
| Upregulated | |||
| GO.0065008 | Regulation of biological quality | MAPK1, SOX9, PRDX1, IL1B, CAPG, CTSK, FGFR4, COL3A1, AURKB, MAFA, EPHB3, MEF2C, DKK1, GIPC1, SERPINB2, HRAS | 1.90E-04 |
| GO.0000165 | MAPK cascade | MAPK1, SOX9, IL1B, FGFR4, FGF5, MEF2C, HRAS | 1.90E-04 |
| GO.0006468 | Protein phosphorylation | MAPK1, SOX9, IL1B, FGFR4, FGF5, AURKB, EPHB3, MEF2C, HRAS | 4.00E-04 |
| GO.1902533 | Positive regulation of intracellular signal transduction | MAPK1, SOX9, IL1B, FGFR4, COL3A1, FGF5, MEF2C, DKK1, HRAS | 4.40E-04 |
| GO.0050804 | Modulation of chemical synaptic transmission | MAPK1, IL1B, MEF2C, DKK1, GIPC1, HRAS | 6.40E-04 |
| GO.0007166 | Cell surface receptor signalling pathway | ITGB4, MAPK1, SOX9, IL1B, FGFR4, COL3A1, FGF5, EPHB3, MEF2C, DKK1, SERPINB2, HRAS | 6.60E-04 |
| GO.1902531 | Regulation of intracellular signal transduction | MAPK1, SOX9, PRDX1, IL1B, FGFR4, COL3A1, FGF5, AURKB, MEF2C, DKK1, HRAS | 6.60E-04 |
| GO.0009967 | Positive regulation of signal transduction | MAPK1, SOX9, IL1B, FGFR4, COL3A1, FGF5, MEF2C, DKK1, GIPC1, HRAS | 9.70E-04 |
| GO.0032872 | Regulation of stress-activated MAPK cascade | MAPK1, PRDX1, IL1B, DKK1, HRAS | 9.70E-04 |
| GO.0008283 | Cell population proliferation | MAPK1, SOX9, PRDX1, FGF5, AURKB, MEF2C, HRAS | 0.0014 |
| GO.0051781 | Positive regulation of cell division | IL1B, FGF5, AURKB, GIPC1 | 0.0014 |
| GO.0007167 | Enzyme-linked receptor protein signalling pathway | MAPK1, SOX9, FGFR4, COL3A1, FGF5, EPHB3, HRAS | 0.0017 |
| GO.0043408 | Regulation of MAPK cascade | MAPK1, PRDX1, IL1B, FGFR4, MEF2C, DKK1, HRAS | 0.0017 |
| GO.0043406 | Positive regulation of MAP kinase activity | MAPK1, IL1B, MEF2C, DKK1, HRAS | 0.0017 |
| GO.0071363 | Cellular response to growth factor stimulus | MAPK1, SOX9, FGFR4, COL3A1, FGF5, MEF2C | 0.0019 |
| Downregulated | |||
| GO.0035988 | Chondrocyte proliferation | FGFR3, HMGA2 | 0.0034 |
| GO.0048513 | Animal organ development | SMAD2, MCM2, ANLN, HPRT1, FGFR3, HMGA2 | 0.0045 |
| GO.0001706 | Endoderm formation | SMAD2, HMGA2 | 0.0241 |
| GO.0001707 | Mesoderm formation | SMAD2, HMGA2 | 0.0241 |
| GO.0002062 | Chondrocyte differentiation | FGFR3, HMGA2 | 0.0241 |
| GO.0035265 | Organ growth | SMAD2, FGFR3 | 0.0241 |
| GO.0001501 | Skeletal system development | SMAD2, FGFR3, HMGA2 | 0.0241 |
| GO.1903047 | Mitotic cell cycle process | MCM2, ANLN, HMGA2 | 0.0241 |
| GO.0065003 | Protein-containing complex assembly | SMAD2, MCM2, ANLN, HPRT1 | 0.0241 |
| GO.0022607 | Cellular component assembly | SMAD2, MCM2, ANLN, HPRT1, HMGA2 | 0.0241 |
| GO.0008283 | Cell population proliferation | HPRT1, FGFR3, HMGA2 | 0.0292 |
| GO.0031497 | Chromatin assembly | MCM2, HMGA2 | 0.0307 |
| GO.0030154 | Cell differentiation | SMAD2, ANLN, HPRT1, FGFR3, HMGA2 | 0.0307 |
| GO.0048705 | Skeletal system morphogenesis | SMAD2, FGFR3 | 0.0374 |
| GO.0060485 | Mesenchyme development | SMAD2, HMGA2 | 0.0374 |