Table 4.
Discordant PIK3CA mutation results (N = 20) between plasma and tissue samples.
| Patient ID | Mutation(s) in plasma (AF %) | z-score | Mutation in tissue (MAF %) | Source of tissue | Time interval between plasma and tissue collectiona |
|---|---|---|---|---|---|
| B176 | H1047R (0.27) | 7.39 | ND | Metastasis | −11 days |
| B195 | H1047R (2.97) | 4.18 | ND | Metastasis | 6 days |
| B200 | H1047R (0.98) | 1.75 | ND | Metastasis | 4.4 months |
| B201 | E542K (0.46) | 2.11 | H1047R (21.1) | Metastasis | 22 days |
| B205 | H1047R (0.72) | 7.90 | ND | Metastasis | 14 days |
| B207 | H1047R (0.97) | 3.30 | ND | Metastasis | −3.8 months |
| B209 | H1047R (1.17) | 1.22 | ND | Primary | 6.6 months |
| B212 | ND | 3.19 | E545K (30.7) | Primary | −9.9 months |
| B218 | ND | 3.40 | E542K (23.7) | Metastasis | 16.1 months |
| B235 | E542K (1.34), H1047R (0.77) | 1.69 | ND | Primary | 22.6 months |
| B242 | ND | 2.07 | E545K (55.8) | Metastasis | 10.1 months |
| B275 | ND | 2.51 | H1047R (25.6) | Primary | 2.2 months |
| B285 | H1047R (0.31) | 1.81 | ND | Metastasis | −4.6 months |
| B296 | H1047R (0.58) | 0.77 | H1047L (30.5) | Metastasis | 2.3 months |
| B303 | H1047R (0.42) | 0.81 | E542K (29.5) | Metastasis | 7 days |
| B304 | H1047R (1.08) | 2.20 | ND | Primary | 139.2 months |
| B307 | H1047R (0.41) | 1.51 | H1047L (25.9) | Primary | 88.5 months |
| B341 | ND | 2.43 | E545K (30.9) | Primary | 20 days |
| B350 | H1047R (0.47) | 1.29 | ND | Metastasis | 1.8 months |
| B354 | ND | 0.94 | H1047R (15.9) | Metastasis | 119.0 months |
ND no mutation detected.
aNegative numbers mean that plasma samples were analysed at an earlier date than tissue samples.