Table 1.
Clinical and biological characteristics of the patients according to their ctDNA status.
| Characteristic | ctDNA negative N = 110a | ctDNA positive N = 145a | P-valueb |
|---|---|---|---|
| Age | 67 (61, 71) | 64 (56, 68) | <0.001 |
| Gender | 0.8 | ||
| Female | 47 (43%) | 58 (40%) | |
| Male | 63 (57%) | 87 (60%) | |
| WHO Score | 0.10 | ||
| 0 | 54 (49%) | 55 (38%) | |
| 1–2 | 56 (51%) | 90 (62%) | |
| CA19.9 UI/mL | 708 (76, 3167) | 3154 (165, 20,000) | 0.001 |
| Unknown | 2 | 9 | |
| CA19.9 median UI/mL | |||
| ≤1366 | 68 (63%) | 54 (40%) | <0.001 |
| >1366 | 40 (37%) | 82 (60%) | |
| Unknown | 2 | 9 | |
| NLRc | <0.001 | ||
| <3.2 | 73 (84%) | 54 (67%) | |
| ≥3.2 | 37 (16%) | 90 (33%) | |
| Unknown | 0 | 1 | |
| Liver metastasis | 76 (69%) | 138 (95%) | <0.001 |
| Number of metastatic sites | 0.5 | ||
| 1 | 68 (62%) | 83 (57%) | |
| ≥2 | 42 (38%) | 62 (43%) |
Bold values indicate statistical significance p < 0.05.
aStatistics presented: median (IQR); n (%).
bStatistical tests performed: Wilcoxon rank-sum test; Chi-square test of independence.
cNLR Neutrophils Lymphocytes ratio.