Figure 3.

The establishment of the postnatal enthesis depends on either (A) migratory (e.g., replacement) or (B) stationary (e.g., maintenance and differentiation) of the progenitor cells at the interface between tendon and bone. (C) Enthesis maturation results in dynamic remodeling of collagen-rich extracellular matrix, with predominantly collagen type I (Col1) in tendon, collagen type II (Col2) in the cartilage template, and deposition of collagen type X at the enthesis and in the secondary ossification center. Timelines shown are representative of mouse enthesis development; P = postnatal day. Modified from (31,46)