. Author manuscript; available in PMC: 2023 Feb 28.

Published in final edited form as: J Mol Biol. 2021 Aug 3;434(4):167183. doi: 10.1016/j.jmb.2021.167183

Table 1.

Monogenic diseases associated with inflammasome genes

Gene	Disease	Current Treatments
*MEFV*	Familial Mediterranean Fever (FMF)	Colchicine, canakinumab
*NLRC4*	Autoinflammation with infantile enterocolitis (AIFEC)	Under investigation
*NLRP3*	Cryopyrin-associated Periodic Syndrome (CAPS)	Corticosteroids, canakinumab, anakinra, rilonacept
	Familial Cold Autoinflammatory Syndrome (FCAS)
	Neonatal-onset Multisystem Inflammatory Disease (NOMID)
	Muckle-Wells Syndrome (MWS)
*NLRP1*	Multiple Self-healing Palmoplantar Carcinoma (MSPC)	Retinoids, surgical removal of carcinomas
	Juvenile Recurrent Respiratory Papillomatosis (JRRP)	Surgical removal of papillomas
	Familial Keratosis Lichenoides Chronica (FKLC)	Retinoids, corticosteroids, phototherapy