Table 2.
Pathways upregulated by 8 μg/g miR-146a-5p mimetic in visceral adipose tissue from df/df mice
| KEGG pathway | P-value |
|---|---|
| Upregulated | |
| Oxidative phosphorylation | 0.0001 |
| Ribosome | 0.0002 |
| Fatty acid degradation | 0.0005 |
| Peroxisome | 0.0012 |
| PPAR signaling pathway | 0.0039 |
| Valine, leucine, and isoleucine degradation | 0.0048 |
| Cardiac muscle contraction | 0.0081 |
| Citrate cycle (TCA cycle) | 0.0082 |
| Metabolism of xenobiotics by cytochrome P450 | 0.0083 |
| Alanine, aspartate, and glutamate metabolism | 0.0114 |
| Drug metabolism–cytochrome P450 | 0.0158 |
| Propanoate metabolism | 0.0185 |
| Butanoate metabolism | 0.0198 |
| Retinol metabolism | 0.0251 |
| Drug metabolism–other enzymes | 0.0258 |
| Primary bile acid biosynthesis | 0.0297 |
| Tryptophan metabolism | 0.0300 |
| Glycolysis/gluconeogenesis | 0.0353 |
| Tyrosine metabolism | 0.0403 |
| Glycerophopholipid metabolism | 0.0408 |
Pathways with p < 0.05 were considered significant