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. 2022 Jan 20;12:778019. doi: 10.3389/fendo.2021.778019

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Copyright © 2022 Du, He, Xu, Qu, Cui, Zhang, Zhang, Li and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone remodeling is influenced by temperature. (A) Calcium and alizarin red double labeling were performed to determine the bone formation rate. (B, C) BFR/BS and MAR shown in A were calculated. (D) Representative TRAP staining of femur bone sections. (E) Histomorphometric quantification of Oc.N/BS in femur bone. (F–H) CTX-1, P1NP and IL-6 in the serum were detected by ELISA. Black arrows: TRAP positive cells. Data are shown as the mean ± SD (n=5 per group). Significance (p-value) was calculated using two-way ANOVA, *p < 0.05; 1 day (1 d), 14 days (14 d), 28 days (28 d), Normal: mice at room temperature (23°C), Cold: mice at 4°C.