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. 2021 Sep 30;44(1):195–209. doi: 10.1007/s11357-021-00450-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Distribution across groups of the scores in the neuropsychological variables selected (i.e., ADAS-11, MoCA, TMT-A) at the 48-month follow-up evaluation timepoint; black lines show mean and standard deviation for each group and variable. Significant between-group differences are marked with an *, generally showing that APOE4 + _Aβ + individuals are the ones performing the worst in these cognitive tests