Table 1.

Results of the multivariate analysis of variance (MANOVA, statistical analysis 1)

Structure	Timepoint	Variable	F2, 104	p	${\eta }^2$	Power
GCC	Acute	Age	19.85	0.001	0.28	1.00
		Sex	0.04	0.958	0.00	0.06
		CMBs	0.87	0.423	0.02	0.20
	Chronic	Age	22.70	0.001	0.30	1.00
		Sex	0.21	0.808	0.00	0.08
		CMBs	0.21	0.812	0.00	0.08
BCC	Acute	Age	9.07	0.001	0.21	1.00
		Sex	0.62	0.604	0.02	0.18
		CMBs	0.85	0.468	0.02	0.23
	Chronic	Age	6.82	0.001	0.17	0.97
		Sex	1.81	0.150	0.05	0.46
		CMBs	0.03	0.993	0.00	0.05
SCC	Acute	Age	4.03	0.021	0.07	0.71
		Sex	0.87	0.424	0.02	0.20
		CMBs	1.08	0.342	0.02	0.24
	Chronic	Age	0.40	0.671	0.01	0.11
		Sex	0.54	0.585	0.01	0.14
		CMBs	0.38	0.688	0.01	0.11
ILF	Acute	Age	4.20	0.020	0.08	0.73
		Sex	1.85	0.162	0.03	0.38
		CMBs	1.04	0.259	0.02	0.23
	Chronic	Age	3.26	0.042	0.06	0.61
		Sex	0.32	0.725	0.01	0.10
		CMBs	0.72	0.042	0.06	0.61
MdLF	Acute	Age	4.25	0.017	0.08	0.73
		Sex	2.34	0.102	0.04	0.46
		CMBs	0.54	0.587	0.01	0.14
	Chronic	Age	3.20	0.045	0.06	0.60
		Sex	1.00	0.371	0.02	0.22
		CMBs	2.73	0.070	0.05	0.53
IOFF	Acute	Age	0.43	0.653	0.01	0.12
		Sex	1.26	0.287	0.02	0.27
		CMBs	1.44	0.242	0.03	0.30
	Chronic	Age	0.12	0.886	0.00	0.07
		Sex	5.59	0.005	0.10	0.85
		CMBs	1.14	0.249	0.03	0.30
Sup-F	Acute	Age	8.09	0.001	0.14	0.95
		Sex	1.19	0.309	0.02	0.26
		CMBs	0.44	0.643	0.01	0.12
	Chronic	Age	5.64	0.005	0.10	0.85
		Sex	1.28	0.283	0.02	0.27
		CMBs	0.14	0.879	0.00	0.07
Sup-T	Acute	Age	8.76	0.001	0.14	0.97
		Sex	3.26	0.042	0.06	0.61
		CMBs	0.12	0.886	0.00	0.07
	Chronic	Age	13.70	0.001	0.21	1.00
		Sex	0.32	0.729	0.01	0.10
		CMBs	0.45	0.641	0.01	0.12

The mean FAs of the left and right WM structures of interest were included as one bivariate vector of dependent variables. Participants’ ages, sex, and CMB counts were independent variables. Acute and chronic data were acquired $\sim$ 7 days and $\sim$ 6 months post-injury, respectively. Null hypotheses were tested at a significance level of $\alpha$ = 0.05, and significant findings are in  bold case. F statistics with 2 and 104 degrees of freedom, effect sizes (Cohen’s ${\eta }^2$), and statistical power are listed

BCC, body of the corpus callosum; CMB, cerebral microbleed; CST, corticospinal tract; FA, fractional anisotropy; GCC, genu of the corpus callosum; ILF, inferior longitudinal fasciculus; IOFF, inferior occipitofrontal fasciculus; MdLF, middle longitudinal fasciculus; SCC, splenium of the corpus callosum; Sup-F, superficial frontal; Sup-P, superficial parietal; Sup-T, superficial temporal; WM, white matter