. 2021 Oct 26;44(1):83–102. doi: 10.1007/s11357-021-00459-2

Table 3.

Results of MANOVA investigating whether each predictor (age, sex, or CMB count) contributed significantly, above and beyond the contributions of all other predictors, to the changes in FA means observed in various structures (statistical analysis 3)

Structure	Stage	Variable(s)	F	df₁	df₂	p	$η^{2}$	Power
GCC	Acute	CMB	1.20	7	11	0.38	0.43	0.31
		Age	1.82	45	11	0.14	0.88	0.64
		Sex	0.67	2	10	0.54	0.12	0.13
		Sex × age	0.64	6	11	0.70	0.26	0.17
		CMBs × age	1.38	22	11	0.30	0.73	0.45
	Chronic	CMB	0.73	7	11	0.65	0.32	0.19
		Age	5.52	46	11	0.01	0.96	1.00
		Sex	0.16	2	10	0.86	0.03	0.07
		Sex × age	3.92	6	11	0.02	0.68	0.81
		CMB × age	3.02	21	11	0.03	0.85	0.85
BCC	Acute	CMB	1.14	7	11	0.41	0.42	0.29
		Age	2.61	45	11	0.04	0.91	0.83
		Sex	0.01	3	9	1.00	0.00	0.05
		Sex × age	1.85	6	11	0.18	0.50	0.45
		CMB × age	1.00	22	11	0.53	0.67	0.33
	Chronic	CMB	3.33	7	11	0.04	0.68	0.76
		Age	3.99	46	11	0.01	0.94	0.96
		Sex	1.04	3	9	0.42	0.26	0.20
		Sex × age	1.68	6	11	0.22	0.48	0.41
		CMB × age	1.89	21	11	0.14	0.78	0.61
SCC	Acute	CMB	0.61	7	11	0.74	0.28	0.17
		Age	1.34	45	11	0.31	0.85	0.48
		Sex	0.03	2	10	0.97	0.01	0.05
		Sex × age	0.46	6	11	0.82	0.20	0.13
		CMB × age	0.61	22	11	0.85	0.55	0.20
	Chronic	CMB	1.14	7	11	0.41	0.42	0.29
		Age	2.33	46	11	0.06	0.91	0.78
		Sex	1.20	2	10	0.34	0.19	0.21
		Sex × age	1.37	6	11	0.31	0.43	0.34
		CMB × age	1.79	21	11	0.16	0.77	0.58
ILF	Acute	CMB	1.82	7	11	0.18	0.54	0.46
		Age	2.49	45	11	0.05	0.91	0.81
		Sex	0.24	2	10	0.79	0.05	0.08
		Sex × age	1.11	6	11	0.42	0.38	0.27
		CMB × age	1.91	22	11	0.13	0.79	0.62
	Chronic	CMB	2.75	7	11	0.07	0.64	0.66
		Age	1.03	46	11	0.52	0.81	0.37
		Sex	0.46	2	10	0.64	0.08	0.11
		Sex × age	2.16	6	11	0.13	0.54	0.52
		CMB × age	1.21	21	11	0.39	0.70	0.39
MdLF	Acute	CMB	1.53	7	11	0.25	0.49	0.39
		Age	1.20	45	11	0.39	0.83	0.43
		Sex	1.15	2	10	0.35	0.19	0.20
		Sex × age	0.89	6	11	0.53	0.33	0.22
		CMB × age	1.24	7	11	0.37	0.71	0.41
	Chronic	CMB	3.34	45	11	0.04	0.68	0.76
		Age	2.61	2	10	0.04	0.92	0.83
		Sex	0.85	6	11	0.45	0.15	0.16
		Sex × age	0.85	22	11	0.56	0.32	0.21
		CMB × age	1.51	7	11	0.24	0.74	0.49
IOFF	Acute	CMB	0.52	46	11	0.81	0.25	0.15
		Age	1.09	45	11	0.47	0.82	0.39
		Sex	1.11	2	10	0.37	0.18	0.19
		Sex × age	1.11	6	11	0.42	0.38	0.27
		CMB × age	1.17	22	11	0.41	0.70	0.38
	Chronic	CMB	0.71	7	11	0.66	0.31	0.19
		Age	1.06	46	11	0.49	0.82	0.38
		Sex	1.46	2	10	0.28	0.23	0.24
		Sex × age	0.83	6	11	0.57	0.31	0.21
		CMB × age	1.16	21	11	0.41	0.69	0.38
Sup-F	Acute	CMB	1.35	7	11	0.31	0.46	0.35
		Age	1.59	45	11	0.21	0.87	0.57
		Sex	0.31	2	10	0.74	0.06	0.09
		Sex × age	1.23	6	11	0.36	0.40	0.30
		CMB × age	2.15	22	11	0.09	0.81	0.68
	Chronic	CMB	2.55	7	11	0.08	0.62	0.62
		Age	2.50	46	11	0.05	0.91	0.81
		Sex	1.83	2	10	0.21	0.27	0.29
		Sex × age	2.74	6	11	0.07	0.60	0.63
		CMB × age	1.79	21	11	0.16	0.77	0.58
Sup-T	Acute	CMB	1.10	7	11	0.43	0.41	0.28
		Age	1.90	45	11	0.12	0.89	0.67
		Sex	1.99	2	10	0.19	0.29	0.32
		Sex × age	1.10	6	11	0.42	0.38	0.27
		CMB × age	1.36	22	11	0.30	0.73	0.45
	Chronic	CMB	3.69	7	11	0.03	0.70	0.81
		Age	2.42	46	11	0.06	0.91	0.79
		Sex	0.54	2	10	0.60	0.10	0.12
		Sex × age	1.86	6	11	0.18	0.50	0.45
		CMB × age	2.10	21	11	0.10	0.80	0.66
Sup-P	Acute	CMB	2.86	7	11	0.06	0.65	0.68
		Age	1.62	45	11	0.19	0.87	0.58
		Sex	0.27	2	10	0.77	0.05	0.08
		Sex × age	1.68	6	11	0.22	0.48	0.41
		CMB × age	0.90	22	11	0.60	0.64	0.29
	Chronic	CMB	1.05	7	11	0.45	0.40	0.27
		Age	1.11	46	11	0.46	0.82	0.40
		Sex	0.16	2	10	0.85	0.03	0.07
		Sex × age	2.02	6	11	0.15	0.52	0.49
		CMB × age	0.96	21	11	0.56	0.65	0.31
CST	Acute	CMB	1.14	7	11	0.41	0.42	0.29
		Age	1.53	45	11	0.23	0.86	0.55
		Sex	1.16	2	10	0.35	0.19	0.20
		Sex × age	0.72	6	11	0.65	0.28	0.18
		CMB × age	1.10	22	11	0.46	0.69	0.36
	Chronic	CMB	1.20	7	11	0.38	0.43	0.31
		Age	1.01	46	11	0.53	0.81	0.36
		Sex	0.69	2	10	0.52	0.12	0.14
		Sex × age	1.19	6	11	0.38	0.39	0.29
		CMB × age	1.62	21	11	0.21	0.76	0.53

The acute and chronic time points correspond to $\sim$ 7 days and $\sim$ 6 months post-injury, respectively. Null hypotheses were tested at a significance level of $α$ = 0.05, and findings that are both significant and well-powered (power > 0.8) are in bold case. F statistics, numerator and denominator degrees of freedom (df₁ and df₂), effect sizes (Cohen’s $η^{2}$ ), and statistical power are listed

BCC, body of the corpus callosum; CMB, cerebral microbleed; CST, corticospinal tract; FA, fractional anisotropy; GCC, genu of the corpus callosum; ILF , inferior longitudinal fasciculus; IOFF, inferior occipitofrontal fasciculus; MdLF, middle longitudinal fasciculus; SCC , splenium of the corpus callosum; Sup-F, superficial frontal; Sup-P, superficial parietal; Sup-T, superficial temporal; WM, white matter