Fig. 3.

Higher polygenic risk scores for obsessive–compulsive disorder in multiple attempters (N = 64) compared to single attempters (N = 52). A Linear regression was performed with the PRS for OCD as the independent variable and the number of attempts as the dependent variable. The x-axis illustrates the p value thresholds used to filter the variants from the GWAS for OCD. The y-axis illustrates R², which represents the proportion of the variance explained. The p-values for the associations are shown above each bar. *Asterisk indicates nominal significance (p < 0.05). Model using a p value threshold of 0.001 was selected as the best-fit model. B Scatter plot illustrates the relationship between PRS for OCD and the number of attempts. The red line and green shading illustrate the best-fit linear regression model and 95% confidence intervals, respectively. The x-axis illustrates the PRS calculated using the best-fit model. Since the PRS was standardized, x-axis ticks were marked with the mean and standard deviation. C Quantile plot illustrates the pattern of the ORs for multiple attempters vs. single attempters across the quantiles of the PRS for OCD. The x-axis illustrates the last four quantiles of all five quantiles of the PRS for OCD. The y-axis illustrates the OR for multiple attempters (N = 64) vs single attempters (N = 52) in each quantile compared to the first quantile. The OR from the total sample was also shown after the dotted vertical line. The points and lines illustrate the ORs and 95% confidence intervals, respectively. D Density plot illustrates the distribution of the PRS for OCD across non-attempters (N = 262), single attempters (N = 64), multiple attempters (N = 52), and lifetime attempters (single or multiple) (N = 121). The PRS for OCD was significantly different between single attempters vs multiple attempters, but not between non-attempters vs single attempters. PRS polygenic risk score, OCD obsessive–compulsive disorder, GWAS genome-wide association study, OR odds ratio