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. 2022 Jan 20;12:831997. doi: 10.3389/fonc.2022.831997

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Copyright © 2022 Jiang, Yuan, Tang, Wang, Zhang, Cho and Duan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Over-expression of miRNA-30a-5p inhibits cancer stem cell maintenance in LUAD. (A) The correlation between miRNA-30a-5p and cancer stem cell maintenance-related factors, including SOX2, CD44, OCT4, and NANO in TCGA-LUAD, was examined using Pearson’s correlation analysis. (B, C) Relative mRNA expressions of cancer stem cell marker genes, including CD44, OCT4, SOX2, NANOG in A549, and SPC-A1cells, were examined by Real-time RT-PCR upon over-expression of miRNA-30a-5p. (D, E) Tumor sphere formation abilities of indicated cells after over-expression of miRNA-30a-5p were examined by tumorsphere assay. Scale bar=50 μm. . ***P < 0.001.