Table 1. Demographics and clinical characteristics of mild cognitive impairment subjects.
| Variable | Total | Normal weight (BMI<23) | Overweight (23≤BMI<25) | Obese (BMI≥25) | p-value | |
|---|---|---|---|---|---|---|
| No. | 3,038 | 1,317 (43.4) | 802 (26.4) | 919 (30.3) | ||
| Age (yr) | 73.55±5.13 | 74.09±5.35 | 73.24±5.27 | 73.05±5.23 | <0.001 | |
| Sex | ||||||
| Female | 2,041 (67.2) | 885 (67.2) | 514 (64.1) | 642 (69.9) | 0.039 | |
| Education (yr) | 7.78 (5.44) | 7.81 (5.38) | 8.02 (5.56) | 7.52 (5.42) | 0.156 | |
| No education | 529 (17.4) | 212 (16.1) | 144 (18.0) | 173 (18.8) | ||
| ≤6 yr | 1,037 (34.1) | 466 (35.4) | 251 (31.3) | 320 (34.8) | ||
| 7–12 yr | 916 (30.2) | 405 (30.8) | 240 (29.9) | 271 (29.5) | ||
| ≥13 yr | 556 (18.3) | 234 (17.8) | 167 (20.8) | 155 (16.9) | ||
| Family history | ||||||
| Dementia | 343 (11.3) | 144 (21.2) | 79 (18.9) | 120 (24.1) | 0.153 | |
| Stroke | 300 (10.0) | 124 (9.5) | 68 (8.6) | 108 (12.0) | 0.190 | |
| APOE ε4 | ||||||
| APOE ε4(+) | 988 (32.5) | 464 (35.2) | 242 (30.2) | 282 (30.7) | 0.020 | |
| BMI (kg/m2) | 23.66 (3.13) | 20.94 (1.63) | 24.01 (0.58) | 27.27 (2.10) | <0.001 | |
| Comorbid conditions | ||||||
| Hypertension | 1,557 (51.3) | 549 (41.8) | 409 (51.1) | 599 (65.3) | <0.001 | |
| Hyperlipidemia | 639 (21.0) | 213 (16.2) | 172 (21.5) | 254 (27.8) | <0.001 | |
| Diabetes mellitus | 684 (22.5) | 254 (19.3) | 198 (24.8) | 232 (25.4) | 0.001 | |
| Cardiac disease | 484 (15.9) | 169 (12.9) | 139 (17.4) | 176 (19.3) | <0.001 | |
| Stroke | 97 (3.2) | 31 (2.4) | 21 (2.6) | 45 (4.9) | 0.002 | |
| Brain trauma | 78 (2.6) | 36 (2.8) | 18 (2.3) | 24 (2.7) | 0.788 | |
| CDR | ||||||
| 0 | 170 (5.6) | 61 (4.6) | 56 (7.0) | 53 (5.8) | ||
| 0.5 | 2,868 (94.4) | 1,256 (95.4) | 746 (93.0) | 866 (94.2) | 0.071 | |
| Ischemic change | ||||||
| Mild | 2,631 (86.6) | 1,150 (88.1) | 691 (87.1) | 790 (86.7) | 0.591 | |
| Moderate | 378 (12.4) | 155 (11.9) | 102 (12.9) | 121 (13.3) | 0.591 | |
Data are shown as mean±standard deviation or number (%).
BMI: body mass index, APOE: apolipoprotein E, CDR: clinical dementia rating.