TABLE 1.
The 39 different gut-derived metabolites of MCAO/R male rats were obtained from the negative ion scan modes.
| Metabolites | RT | Quant mass | VIP | p-value | Log2(FC) |
|---|---|---|---|---|---|
| Sphingosine 1-phosphate | 310.29 | 378.24[M-H]- | 1.12 | 3.77E-02 | −0.57 |
| Linoleic acid | 63.61 | 279.23[M-H]- | 1.14 | 4.81E-02 | −0.69 |
| N-Acetylaspartylglutamic acid | 456.2 | 303.08[M-H]- | 1.16 | 3.80E-02 | 1.14 |
| Ascorbic acid | 93.64 | 175.02[M-H]- | 1.18 | 1.38E-02 | 0.91 |
| N-Acetylornithine | 377.57 | 173.09[M-H]- | 1.21 | 7.68E-03 | −0.7 |
| 1,3,5-Trihydroxybenzene | 322.64 | 125.02[M-H]- | 1.23 | 2.60E-02 | −0.26 |
| Terephthalic acid | 395.93 | 165.02[M-H]- | 1.24 | 2.46E-02 | 0.34 |
| N-Formyl-L-aspartate | 410.2 | 160.02[M-H]- | 1.24 | 2.14E-02 | 0.31 |
| Creatinine | 182.8 | 112.05[M-H]- | 1.29 | 1.30E-02 | 0.29 |
| L-Glutamine | 393.03 | 145.06[M-H]- | 1.29 | 2.41E-02 | 0.19 |
| L-Proline | 330.94 | 114.06[M-H]- | 1.3 | 3.48E-02 | 0.48 |
| beta-Alanine | 321.42 | 88.04[M-H]- | 1.31 | 3.65E-02 | 0.66 |
| Imidazoleacetic acid | 290.95 | 125.03[M-H]- | 1.32 | 2.08E-02 | 0.26 |
| Dodecanoic acid | 49.09 | 199.17[M-H]- | 1.35 | 3.37E-02 | −0.67 |
| L-Phenylalanine | 279.35 | 164.07[M-H]- | 1.35 | 1.17E-02 | 0.63 |
| 1H-Indole-3-acetamide | 48.56 | 173.07[M-H]- | 1.35 | 3.16E-02 | 0.86 |
| L-Methionine | 304.47 | 148.04[M-H]- | 1.36 | 1.42E-02 | 0.52 |
| Cortisone | 149.82 | 359.19[M-H]- | 1.37 | 3.18E-02 | −1.98 |
| L-Asparagine | 395.75 | 131.05[M-H]- | 1.39 | 1.83E-02 | 0.5 |
| Cytidine | 260.52 | 242.08[M-H]- | 1.46 | 1.67E-02 | −0.75 |
| 5-Aminopentanoic acid | 320.56 | 116.07[M-H]- | 1.49 | 1.07E-02 | 0.7 |
| Indoleacetaldehyde | 62.75 | 158.06[M-H]- | 1.5 | 7.13E-03 | 0.59 |
| m-Coumaric acid | 56.69 | 163.04[M-H]- | 1.5 | 1.85E-02 | 0.95 |
| D-Glucose | 238.49 | 179.06[M-H]- | 1.52 | 9.83E-03 | 0.41 |
| 2-Pyrocatechuic acid | 25.4 | 153.02[M-H]- | 1.52 | 1.83E-02 | 2.09 |
| Creatine | 34.32 | 130.07[M-H]- | 1.52 | 3.48E-03 | 0.6 |
| p-Hydroxyphenylacetic acid | 49.57 | 151.04[M-H]- | 1.54 | 4.23E-03 | 0.86 |
| Phthalic acid | 374.2 | 165.02[M-H]- | 1.55 | 4.97E-03 | 0.22 |
| 2-Hydroxybutyric acid | 205.48 | 103.04[M-H]- | 1.56 | 3.40E-03 | 0.73 |
| L-Arginine | 534.51 | 173.1[M-H]- | 1.56 | 6.66E-03 | 0.27 |
| Hydroxypropionic acid | 202.85 | 89.02[M-H]- | 1.6 | 4.26E-03 | 0.34 |
| Perillic acid | 60.81 | 165.09[M-H]- | 1.6 | 9.91E-04 | −1.15 |
| Alpha-Linolenic acid | 42.06 | 277.22[M-H]- | 1.61 | 9.78E-06 | −1.3 |
| L-Histidine | 395.71 | 154.06[M-H]- | 1.71 | 6.28E-04 | 0.51 |
| Arachidonic acid | 38.79 | 303.23[M-H]- | 1.74 | 6.33E-06 | −1.1 |
| Taurocholic acid | 219.93 | 514.29[M-H]- | 1.75 | 3.46E-02 | 4.67 |
| 3-(3-Hydroxyphenyl)propanoic acid | 171.63 | 165.05[M-H]- | 1.87 | 8.10E-03 | 4.77 |
| Mesaconic acid | 208.35 | 129.02[M-H]- | 1.88 | 4.18E-03 | 2.41 |
| Gentisic acid | 66.15 | 153.02[M-H]- | 2.04 | 6.87E-06 | 4.73 |