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. 2022 Jan 20;11:802124. doi: 10.3389/fonc.2021.802124

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Copyright © 2022 Zhou, Wu, Wang, Xu, Yan, Tong and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPX7 silencing sensitizes glioma cells to erastin both in vitro and in vivo. (A) CCK-8 assay was applied to analyze the viability of LN229 and T98G cells treated with different concentrations of erastin following the transfection with siGPX7 and siScr. (B) Migration ability of cells was analyzed using wound-healing assay. Scale bar, 250 μm. (C) Invasive ability of cells was evaluated by transwell assay. Scale bar, 100 μm. (D) FITC annexin V and PI apoptosis assay. (E) Knockdown of GPX7 enhanced erastin-induced ferroptosis in vivo. The volume of tumors was shown (F), and the tumor weight was measured at the endpoint (G). (H) Immunohistochemistry staining of xenograft model-derived tumors for GPX7, Ki67, MMP2 and N-Cadherin. Scale bar = 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001. ns, not significant.