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. 2022 Jan 20;11:802124. doi: 10.3389/fonc.2021.802124

Figure 6.

Figure 6

GPX7 is a direct target of miR-29 family. (A) The venn diagram of predicted mRNAs in four different databases. (B) The seed sequences of miR-29 family that match the 3′UTR of GPX7 gene and the reporter vectors containing wild-type or mutant GPX7 3’-UTR. (C) Dual luciferase reporter assays in LN229 and T98G, following cotransfection with miR-29 family and empty vector (pcDNA-3.1) or plasmid containing wild or mutant type 3′UTR of GPX7. (D, E) The mRNA and protein levels of GPX7 in cells transfected with miR-29 family mimic or miR-NC. (F–H) The correlations between GPX7 expression and miR-29 family in TCGA and CGGA. R: Pearson correlation coefficient. *P < 0.05, **P < 0.01, ***P < 0.001.