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. 2022 Jan 20;11:802124. doi: 10.3389/fonc.2021.802124

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Copyright © 2022 Zhou, Wu, Wang, Xu, Yan, Tong and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GPX7 restoration can reverse miR-29b mediated enhancement of ferroptosis-related oxidative stress. LN229 and T98G cells were transfected with miR-29b mimic or cotransfected with miR-29b mimic and GPX7 overexpression plasmid. (A) The reduced GSH level of cells. (B) The Fe2+ concentration was measured by FerroOrange probe. (C) Lipid peroxidation was detected in glioma cells treated with or without fer-1 (2 μM), erastin (10 μM), lip-1 (100 nM) and DFO (100 μM). Within each chart, cells in P3 region in green represent those stained with oxidized dye. *P < 0.05, **P < 0.01, ***P < 0.001. ns, not significant.