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. 2022 Jan 20;11:802124. doi: 10.3389/fonc.2021.802124

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Copyright © 2022 Zhou, Wu, Wang, Xu, Yan, Tong and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergistic inhibitory effects of miR-29b mimic transfection and erastin cotreatment on glioma cells, which can be partially reversed by GPX7 restoration. (A) LN229 and T98G cells transfected with miR-29b mimic or cotransfected with miR-29b mimic and GPX7 overexpression plasmid were treated with erastin at different concentrations. Proliferation ability of cells was evaluated using CCK-8. (B) Wound healing assay. The concentration of erastin is 10 µM. Scale bar, 250 μm. (C) Transwell assay with 10 µM erastin used. Scale bar, 100 μm. (D) Annexin V and PI apoptosis assay. The concentration of erastin is 10 µM. (E) The schematic diagram of the roles of miR-29b/GPX7 in glioma ferroptosis induced by erastin, which was created on the BioRender.com. *P < 0.05, **P < 0.01, ***P < 0.001.