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. 2022 Jan 20;12:792643. doi: 10.3389/fneur.2021.792643

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Copyright © 2022 Petersen, Sharkey, Pal, Shafau, Zenchak-Petersen, Peña, Aggarwal, Prakash and Hochgeschwender.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spinal cord injury model. (A) Schematic of the experimental model with viral injection for BL-OG stimulation in the lumbar enlargement and contusion injury in the thoracic region. (B) Timeline of experimental procedures with the first surgery for lateral ventricle cannula placement and virus injection 3 weeks prior to injury. (C) Expression of AAV 2/9 hSyn-LMO3 in the lumbar spinal cord (arrow pointing to expressing interneurons). The highest levels of expression are restricted to interneuron populations in lamina IV-VIII and X with some expression more dorsal and in lamina IX. (D) Expression of AAV 2/9 Hb9-LMO3 in the lumbar spinal cord (arrow pointing to expressing motor neurons). The Hb9 promoter restricts expression to motor neurons in lamina IX. Some low level of expression does occur throughout other laminae of the cord.