TABLE 2.
Median paired biochemical changes overtime after the introduction of fibrates
| Time of measurement | AST/ULN (n = 27) | AST/ULN percentage difference from baseline | p-value | p-value |
| Comparison with baseline values | Comparison with last measurement | |||
| Baseline | 1.42 | — | — | |
| 1 year | 1.10 | −25.4% | 0.353 | 0.353 |
| 2 years | 1.06 | −26.9% | 0.052 | 0.010 |
| Time of measurement | ALT/ULN (n = 27) | ALT/ULN percentage difference from baseline | p-value | p-value |
| Comparison with baseline values | Comparison with last measurement | |||
| Baseline | 1.52 | — | — | |
| 1 year | 1.13 | −25.7% | 0.287 | 0.287 |
| 2 years | 1.06 | −30% | 0.030 | 0.101 |
| Time of measurement | ALP/ULN (n = 27) | ALP/ULN percentage difference from baseline | p-value | p-value |
| Comparison with baseline values | Comparison with last measurement | |||
| Baseline | 1.73 | — | — | |
| 1 year | 1.61 | −7% | 0.304 | 0.304 |
| 2 years | 1.36 | −21.4% | 0.021 | 0.225 |
| Time of measurement | GGT/ULN (n = 27) | GGT/ULN percentage difference from baseline | p-value | p-value |
| Comparison with baseline values | Comparison with last measurement | |||
| Baseline | 4.60 | — | — | |
| 1 year | 3.22 | −30% | 0.048 | 0.048 |
| 2 years | 3.08 | −33% | 0.036 | 0.278 |
| Time of measurement | TB/ULN (n = 27) | TB/ULN percentage difference from baseline | p-value | p-value |
| Comparison with baseline values | Comparison with last measurement | |||
| Baseline | 0.54 | — | — | |
| 1 year | 0.55 | +1.8% | 0.647 | 0.647 |
| 2 years | 0.43 | −20.4% | 0.820 | 0.386 |
AST, aspartate aminotransferase; ULN, upper limit of normal; UDCA, ursodeoxycholic acid; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; TB, total bilirubin. Data are expressed as ratio between serum measurement and ULN. Wilcoxon test was performed.