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. 2022 Jan 20;8:745638. doi: 10.3389/fmed.2021.745638

Figure 6.

Figure 6

Role of Gα12/13-RhoA-ROCK pathway in mediating BK-induced contractions in murine UBSM. The contractile responses induced by BK (10−5 M) were decreased in the presence of the ROCK inhibitor (Y-27632, 10−5 M, 20 min). (A) The addition of Y-27632 (10−5 M, 20 min) completely suppressed the remaining BK-induced contractile responses in UBSM strips from Gαq/11-KO mice. (B) (A: Mann-Whitney test, B: Kruskal-Wallis test, *p < 0.05, **p < 0.01, and ****p < 0.0001). Case numbers: (A): vehicle: n = 14/8, Y-27632: n = 16/8, (B): vehicle: n = 9/4, Gαq/11-KO + vehicle: n = 8/4, Gαq/11-KO + Y-27632: n = 9/4.