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. 2022 Jan 20;12:824933. doi: 10.3389/fpsyt.2021.824933

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Copyright © 2022 Beversdorf, Sohl, Levitskiy, Tennant, Goin-Kochel, Shaffer, Confair, Middleton and Hicks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcript abundance displaying significant interaction between neurodevelopmental status and presence/absence of GI condition. The whisker box plots represent normalized abundance of microbial RNAs and piRNAs that displayed a significant interaction between neurodevelopmental status (ASD/DD/TD) and presence/absence of any GI condition. These features may provide insight into the unique biology underlying the heightened prevalence of GI conditions in children with ASD. Significance levels: p-val < 0.001 (*), p-val < 0.0001 (**). For all features shown, the adjusted p-value (FDR) <0.05.