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Synthesis of the compounds 56 and 60 of Table 2. Reagents and conditions: (i) n-BuLi, benzaldehyde −78 °C, 3 h (11%); (ii) TFA, Et3SiH, DCM, then H2, 10% Pd/C, MeOH (85%); (iii) HATU, DIPEA, DMF (56: 21%, 60: 30%). (iv) Pd(dppf)Cl2, 2 M aq K2CO3, PhMe:EtOH, then H2, 10% Pd/C, AcOH, MeOH (25% over two steps).
