Scheme 8.
Synthesis of the compounds 71–74 of Table 3. Reagents and conditions: (i) Pd(dppf)Cl2, Na2CO3, toluene:MeOH:H2O, 100 °C, 2 h (115: 57%, 116: 65%, 117: 65%, 118: 68%); (ii) HATU, DIPEA, DMF (71: 88%, 72: 62%, 73: 80%, 74: 63%).
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