Skip to main content
. 2022 Feb 5;229:114059. doi: 10.1016/j.ejmech.2021.114059

Table 7.

In vivo PK data for representative tetrahydronaphthalenes.

No Mouse PK (at 100 mg/kg PO)
 clogPc
AUC inf h∗μg/mLa t½ (h)b
BDQ 21 56 7.25
5 21 11 6.76
18 47 9 5.40
32 17 7 6.78
71 25 6.1 6.70
72 39 16 6.70
77 67 14 6.51
79 30 6.5 6.32
a

Drug exposure (AUC) after a single dose of 100 mg/kg.

b

Drug plasma half-life (hrs).

c

Calculated using ChemDraw Professional, version 19.0.0.22.