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. 2022 Feb 3;76:103861. doi: 10.1016/j.ebiom.2022.103861

Figure 3.

Fig 3

HIS-SARS2 activates genes related to COVID-19 pathology. (a–c) The relative mRNA expression of the neighboring genes FBXO15, TIMM21, and CYB5A after HIS-SARS2-4 vector transfected in HEK293T cells (a), MRC5 cells (b), and HUVEC cells (c). (d–f) The relative mRNA expression of the distant gene EPN1, MYL9, and ISOC2 after HIS-SARS2-3 vector transfected in HEK293T cells (d), MRC5 cells (e), and HUVEC cells (f). (g–i) The relative mRNA expression of HSA2 after five HIS-SARS2 vectors transfected in HEK293T cells, MRC5 cells, and HUVEC cells. (k) The enrichment of enhancer marker H3K27ac after HIS-SARS-1, HIS-SARS2-1, HIS-SARS2-3, and HIS-SARS2-4 transfection. Data are represented as mean ± SEM (n = 3). P-values were calculated using the unpaired, two-tailed Student's t test by GraphPad Prism 7.0. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, not significant.