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. 2022 Feb 2;10(2):e003082. doi: 10.1136/jitc-2021-003082

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Post-rapid expansion protocol (post-REP) tumor-infiltrating lymphocytes (TIL) 3.0 does not retain the homology and the putative tumor-specific T-cell receptor (TCR). Comparison of (A) TCR richness (paired, n=6), (B) clonality (paired, n=6), (C) Jaccard index (paired, n=6), (D) Morisita Overlap Index (MOI) (paired, n=6) and (E) retained putative tumor-specific TCR (paired, n=6) in pre-REP and post-REP TIL 3.0 expanded product. Statistical analysis was performed by paired t-test on (A), (B), (C), (D) and (E).