Table 1.
Time course of biochemical parameters of our patient during high-dose cholecalciferol supplementation (grey area) and after its discontinuation.
| - | Normal Range | Jan-15 | Mar-15 | Jul-15 | Nov-15 | Apr-16 | Sep-16 | Oct-16 | Nov-16 | Jan-17 | Apr-17 | Jan-18 | May-18 | Nov-18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Months from Baseline | - | 0 | 2 | 6 | 9 | 14 | 19 | 20 | 21 | 23 | 26 | 35 | 39 | 45 |
| Cumulative dose of cholecalciferol (x103 UI) | 0 | 4,200 | 16,200 | 33,000 | 54,000 | 78,000 | - | - | - | - | - | - | - | |
| Average of daily dose of cholecalciferol (UI/day) | 0 | 70,000 | 90,000 | 110,000 | 120,000 | 130,000 | - | - | - | - | - | - | - | |
| 25-OH Vitamin D (nmol/L) | 75 – 250 | 12.3 | >375 | >375 | >375 | >375 | 920 | 688 | 1028 | 610 | 788 | 273 | 239 | 223 |
| Serum Calcium (mmol/L) | 2.13 – 2.63 | 2.38 | 2.33 | 2.28 | 2.23 | 2.40 | 3.23 | 2.68 | 2.75 | 2.55 | 2.43 | 2.43 | 2.28 | 2.45 |
| Serum Phosphorus (mmol/L) | 0.81 – 1.65 | 1.06 | 1.03 | 1.13 | 1.19 | 1.29 | 0.90 | 0.97 | 1.00 | 0.94 | 1.06 | 1.06 | 0.87 | 1.00 |
| Serum Ca/P ratio | <2.6 | 2.23 | 2.25 | 2.02 | 1.86 | 1.86 | 3.57 | 2.76 | 2.75 | 2.73 | 2.28 | 2.28 | 2.61 | 2.45 |
| Serum PTH (pg/mL) | 15 – 88 | 108 | 47.1 | 40 | 25 | 19 | 2.3 | 6.7 | 7.7 | 36.8 | 46.7 | 30.7 | 86.2 | - |
| Creatinine (µmol/L) | 44.0 – 105.6 | 61.6 | 70.4 | 70.4 | 70.4 | 79.2 | 220.1 | 180.4 | 117.9 | 95.9 | 79.2 | 78.3 | 81.9 | 82.7 |
| eGFR (ml/min/1.73m2) | >60 | >60 | >60 | >60 | >60 | >60 | 20 | 23 | 30 | 57 | >60 | >60 | >60 | >60 |
Abbreviations: Ca/P: serum calcium to phosphorous ratio; eGFR: estimated Glomerular filtration rate (calculated using the CKD-EPI formula normalized for body surface).