Table 2.
Dosage information and biochemical tests of adult patients with vitamin D intoxication.
| Reference | Sex, Age (Years) | Country of Residence | Cholecalciferol Supplementation | Biochemical Parameters at Intoxication | Time to Normalize calcium (Weeks) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Dose (x103 UI) | Daily Dose (UI/day) | Duration (Months) | 25OH- Vitamin D (nmol/L) | Serum Ca (mmol/L) | Serum P (mmol/L) | Serum Creatinine (µmol/L) | Serum PTH (pg/mL) | ||||
| Araki, 2011 (a) [12] | M, 58 | USA | 111,840 | 1,864,000 | 2 | 2800 | 3.75 | ↔ | 158.4 | ↓ | 4 |
| Araki, 2011 (b) [12] | M, 40 | USA | 29,100 | 970,000 | 1 | 1613 | 3.30 | ↔ | 176.0 | ↓ | 4 |
| Auguste, 2019 [18] | M, 54 | Canada | 9,125 | 10,000 | 30 | 240 | 3.05 | 0.94 | 378.5 | 4.72 | 24 |
| Bell, 2013 [13] | F, 67 | Australia | 657,000 | 600,000 | 36 | 913 | 3.28 | - | 325.7 | 20.7 | 20 |
| Chowdry, 2017 (a) [26] | F, 84 | India | 3,600 | 60,000 | 2 | 1155 | 3.80 | 0.90 | 167.2 | 18.0 | - |
| Chowdry, 2017 (b) [26] | F, 71 | India | 5,760 | 64,000 | 3 | 510 | 3.50 | 1.32 | 308.1 | 9 | - |
| Chowdry, 2017 (c) [26] | M, 49 | India | 4,500 | 60,000 | 2.5 | 885 | 3.13 | 1.00 | 246.5 | 13 | - |
| Chowdry, 2017 (d) [26] | F, 56 | India | 6,300 | 60,000 | 3.5 | 1110 | 3.55 | 1.13 | 290.5 | 15.5 | - |
| Chowdry, 2017 (e) [26] | M, 51 | India | 4,500 | 60,000 | 2.5 | 770 | 3.13 | 1.10 | 484.1 | 14.3 | - |
| Chowdry, 2017 (f) [26] | F, 61 | India | 5,640 | 56,400 | 3.4 | 770 | 3.78 | 1.19 | 281.7 | 10 | - |
| Feige, 2018 [27] | M, 53 | Austria | 9,000 | 50,000 | 6 | >400 | 3.30 | 1.48 | 598.5 | 7 | 11 |
| Granado-Lorencio, 2012 [28] | F, 51 | Ecuador | 18,000 | 600,000 | 1 | 2742 | 3.23 | 1.64 | 255.3 | 12 | 4 |
| Guerra, 2016 [17] | M, 70 | Brazil | 90 | 2,000 | 1.5 | 375 | 3.35 | 1.87 | 501.7 | 15.3 | 28 |
| Kaptein, 2010 [14] | F, 75 | Netherlands | 9,000 | 150,000 | 2 | 1375 | 4.00 | 0.87 | 272.9 | 9.4 | 3 |
| Kaur, 2015 (a) [29] | F, 83 | India | 2,880 | 32,000 | 3 | >400 | 2.78 | 1.29 | 96.8 | - | - |
| Kaur, 2015 (b) [29] | M, 61 | India | 3,600 | 60,000 | 2 | 973 | 3.43 | 1.16 | 179.6 | 17.9 | - |
| Kaur, 2015 (c) [29] | M, 46 | India | 2,760 | 46,000 | 2 | 913 | 2.80 | 1.03 | 96.8 | 14.8 | - |
| Kaur, 2015 (d) [29] | M, 51 | India | 3,600 | 60,000 | 2 | 723 | 2.90 | 1.29 | 79.2 | 23 | - |
| Kim, 2017 (a) [8] | M, 75 | USA | 600* | 50,000* | 12 | 608 | 3.85 | - | - | 3.0 | 3 |
| Kim, 2017 (b) [8] | F, 60 | USA | 400 | 40,000 | 10 | 1198 | 2.48 | - | - | 17 | - |
| Klontz, 2007 [15] | F, 58 | USA | 10,416 | 186,900 | 2 | 1173 | 3.75 | 0.80 | 264.1 | 12.0 | 2 |
| Koutkia, 2001 [16] | M, 42 | USA | 113,880 | 156,000 | 24 | 1218 | 3.75 | - | 220.1 | ↔ | 8 |
| Leu, 2008 [30] | F, 60 | Dominican Republic | 42,000 | 600,000 | 2.3 | >375 | 3.80 | - | - | ↓ | 1.4 |
| Marins, 2014 [31] | F, 53 | Brazil | - | 4,000,000 | ‘Some’ | >250 | 3.25 | - | 237.7 | 17.5 | 8 |
| Vieth, 2002 [32] | M, 63 | Canada | 11,900 | 1,700,000 | 7 | 1550 | 3.83 | - | 440.1 | <1 | - |
Abbreviations: USA: United States of America; Ca: calcium; P: phosphorous; PTH: parathyroid hormone. *Ergocalciferol (vitamin D2) and 500 mg calcium-citrate daily.