Figure 2.

Surface engineering of individual DPCs: a) Introduction of G7 PAMAM dendrimers as a building block of HMA formation. b) % retention of surface‐bound MCF‐7 (EpCAM^high; red) and Jurkat (EpCAM^negative; white) cells on Gly‐pEP1 versus G7‐pEP1 upon washing with a high shear flow. c) Schematic illustration of anticipatedly enhanced accessibility of pEP1 with the introduction of PEG spacers on the dendrimer surface. d) Retention of surface‐bound MCF‐7 and Jurkat cells on the HMA surfaces with various molecular weight PEG spacers upon washing. e) Molecular dynamics (MD) modeling of G7‐PEG‐pEP1 configurations with various PEG outer layers after 40 ns of simulation time. All washing steps for cell retention assays were performed at a flow rate of 50 µL min⁻¹, which corresponds to a shear stress of 0.36 dyne cm⁻². Significance levels are indicated as ^# p < 0.10, ^* p < 0.05, ^** p < 0.01, and ^*** p < 0.001, which are analyzed using Student's t‐test.