Table 3. Binding Energies (Kcal mol–1) of Synthesized Analogs (2a–2q) against Urease and α-Glucosidase.
| docking study against urease |
docking study against α-glucosidase |
|||
|---|---|---|---|---|
| compound no. | lowest binding energy (Kcal mol–1) | mean binding energy (Kcal mol–1) | lowest binding energy (Kcal mol–1) | mean binding energy (Kcal mol–1) |
| 2a | –7.98 | –7.63 | –6.68 | –6.14 |
| 2b | –8.74 | –7.70 | –7.20 | –6.59 |
| 2c | –8.65 | –8.59 | –7.29 | –6.64 |
| 2d | –8.24 | –7.51 | –6.31 | –5.72 |
| 2e | –8.23 | –7.87 | –6.78 | –6.16 |
| 2f | –8.47 | –8.00 | –6.78 | –6.16 |
| 2g | –9.16 | –8.31 | –6.59 | –5.95 |
| 2h | –8.40 | –7.81 | –6.25 | –5.59 |
| 2i | –7.81 | –7.49 | –7.19 | –6.35 |
| 2j | –8.68 | –8.15 | –7.58 | –6.79 |
| 2k | –8.41 | –7.86 | –6.65 | –6.05 |
| 2l | –7.85 | –7.38 | –7.67 | –6.69 |
| 2m | –7.74 | –7.14 | –6.53 | –6.04 |
| 2n | –7.74 | –7.32 | –6.51 | –5.99 |
| 2o | –7.78 | –7.33 | –7.48 | –5.91 |
| 2p | –7.65 | –7.14 | –6.57 | –5.93 |
| 2q | –8.32 | –7.96 | –7.35 | –7.35 |
| standard | –8.31 (AHA) | –8.11 (AHA) | –7.98 (MIG) | –7.61 (MIG) |