Table 4. Physicochemical Properties of Synthesized Pyrazoline Analogs (2a–2q).

compound no.	mol. formula	mol. wt (g/mol)	no. HBAa	no. HBDb	mol. Log Pc	mol. Log Sd (mg/L)	mol. PSAe A2	drug-likeness model score
2a	C21H17FN2O	332.13	2	1	5.79	0.65	30.47	0.19
2b	C25H26N2O	370.20	2	1	7.49	0.45	30.47	0.96
2c	C21H17BrN2O	392.05	2	1	6.56	0.42	30.47	0.01
2d	C24H24N2O4	404.17	5	1	5.72	1.63	53.53	0.42
2e	C22H20N2O2	344.15	3	1	5.68	1.27	38.01	0.24
2f	C23H23N3O	357.18	2	1	5.79	1.02	33.27	0.08
2g	C23H22N2O3	374.16	4	1	5.40	2.23	45.73	0.27
2h	C22H18N2O3	358.13	4	2	5.53	2.13	58.88	0.41
2i	C19H16N2OS	320.10	3	1	5.25	8.50	31.49	–0.36
2j	C22H19N3O2	357.15	3	3	4.37	4.05	64.53	0.57
2k	C25H27N3O	385.22	2	1	6.53	0.51	33.20	0.23
2l	C21H18N2O	314.14	2	1	5.73	0.76	30.47	–0.45
2m	C22H17F3N2O	382.13	2	1	6.55	0.46	30.47	–0.69
2n	C22H17F3N2O	382.13	2	1	6.60	0.30	30.47	–0.44
2o	C22H17F3N2O	382.13	2	1	6.67	0.40	30.47	–0.32
2p	C23H22N2O	342.17	2	1	6.82	0.49	30.47	–0.06
2q	C22H17N3O	339.14	3	1	5.33	6.10	47.52	–0.29

^aThe table above depicts all of Lipinski’s RO5 components, that is, the number of HBAs.

^bNumber of HBDs.

^cOctanol–water partition coefficient.

^dMeasured solubility.

^eTotal polar surface area.