Table 1. Summary of Proteins Identified in Parent or PLX/AZD-Resistant Cells Grown in Monolayer or Spheroid Cell Cultures; (A) Total Number of Soluble Proteins Identified in Parent or PLX/AZD-Resistant Cells, where Percentages Indicate the Number of Proteins Identified That Are Common or Unique to Each Culture Condition; and (B) Number of Proteins That Significantly Increased or Decreased in PLX/AZD-Resistant vs Parent Cells by At Least 2-Fold in Resistant Cells (FDR Adjusted p < 0.05); Data Are Representative of Three Independent Samples.

A)	A375 cells	proteins identified in monolayers	proteins identified in spheroids	% common in monolayers and spheroids	% unique to monolayers	% unique to spheroids
	parent	3958	4051	66.3	15.9	17.8
	resistant	4019	4080	65.3	16.7	18.0

B)	culture conditions	proteins that increased	proteins that decreased
	monolayers	182	76
	spheroids	536	355