Table 3. Biological Pathways That Are Downregulated in PLX/AZD-Resistant Cells Grown in Monolayers or Spheroids. Biological Signaling Pathways with Downregulated Activity, as Determined Using Qiagen Ingenuity Pathway Analysis in PLX/AZD-Resistant Monolayers or Spheroids and Compared to Parent Cells, where Significance Thresholds of Benjamini–Hochberg Corrected p < 0.05 and z-Scores Less than −1.5 Were Used to Assign Pathways.

Monolayers
	P-value	z-score
PTEN signaling	0.005	–2.12

Spheroids
sirtuin signaling pathway	<0.001	–2.33