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. 2022 Feb 2;10:3. doi: 10.1186/s40170-022-00279-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — A The effect of selected humanized antibodies (CA9hu-1(HC4LC4) and CA9hu-2(HC4LC5)) on the viability of analyzed cells ± expressing CA IX (C33-a CA IX versus C33-a neo) in the presence of complement determined via Cell Titer Blue Viability Assay. Cancer cells incubated in the absence of humanized antibodies are marked as “no Ab.” Data in the graph represent mean ± standard deviation values. Statistical significance was assessed using Student’s t-test (*P < 0.05, **P < 0.01, ***P < 0.001), n = 2. B Graphical representation of ADCP data. CA9hu-1 and CA9hu-2 antibody variant-dependent cell-mediated phagocytosis. Comparison of CA IX-negative versus CA IX-positive target cell line samples. Statistical significance was assessed using Student’s t-test (*P < 0.05, **P < 0.01, ***P < 0.001), n = 3