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. 2022 Feb 2;22:58. doi: 10.1186/s12935-022-02478-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DDX10 promoted colorectal cancer cell growth and metastasis in vitro. A Expression of DDX10 in several colorectal cancer cell lines by q-PCR; MTT cell proliferation assay was applied. Cell growth rate was significantly suppressed by shDDX10 (B) HCT116 cells (P < 0.001) (C) RKO cells (P < 0.001); D Fluorescence images of HCT116 (P < 0.001) and RKO cells (P < 0.01) were measured via Celigo high-content screening assay. Upper panel was the representative images and lower panel was the growth curve; E Colony formation assays using DDX10‐knockdown HCT116 and RKO cells (P < 0.001); F Cell apoptosis using DDX10‐knockdown HCT116 and RKO cells (P < 0.001); G. Wound-healing assay using DDX10-knockdown HCT116 and RKO cells; H. Transwell migration assay using DDX10-knockdown HCT116 (P < 0.001) and RKO cells (P < 0.01); I. Transwell invasion assays using DDX10-knockdown HCT116 (P < 0.01) and RKO cells (P < 0.001)