Table 2.
Association of HNF1A variants with metabolic syndrome traits in the studied Tunisian population
| rs1169288 | rs2464196 | rs735396 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA + AC | CC | p-value | p-value* | GG + GA | AA | p-value | p-value* | TT + TC | CC | p-value | p-value* | |
| WC (cm) | 101.6 | 102.3 | 0.65 | 1 | 101.6 | 105.3 | 0.035a | 0.105 | 101.5 | 104.3 | 0.013a | 0.039a |
| BMI (kg/m2) | 30.05 | 30.17 | 0.99 | 1 | 29.93 | 30.68 | 0.1 | 0.3 | 29.94 | 30.35 | 0.35 | 1 |
| FPG (mmol/l) | 7.81 | 8.68 | 0.1 | 0.3 | 7.8 | 8.36 | 0.47 | 1 | 7.9 | 7.88 | 0.85 | 1 |
| SBP (mmHg) | 14.01 | 13.81 | 0.48 | 1 | 13.95 | 14.11 | 0.62 | 1 | 13.98 | 13.95 | 0.72 | 1 |
| DBP (mmHg) | 8.08 | 8.08 | 0.99 | 1 | 8.07 | 8.08 | 0.61 | 1 | 8.11 | 7.97 | 0.27 | 0.81 |
| TC (mmol/l) | 5.09 | 5.31 | 0.056 | 0.168 | 5.08 | 5.30 | 0.056 | 0.168 | 5.11 | 5.13 | 0.83 | 1 |
| HDL (mmol/l) | 1.30 | 1.38 | 0.07 | 0.21 | 1.3 | 1.37 | 0.037a | 0.111 | 1.29 | 1.36 | 0.08 | 0.24 |
| LDL (mmol/l) | 3.24 | 3.31 | 0.61 | 1 | 3.23 | 3.34 | 0.45 | 1 | 3.24 | 3.25 | 0.9 | 1 |
| TG (mmol/l) | 1.66 | 1.76 | 0.5 | 1 | 1.66 | 1.71 | 0.96 | 1 | 1.66 | 1.69 | 0.8 | 1 |
Data are presented as means. Linear regression, adjusted for age, sex and BMI, was used to assess genotype phenotype correlations under the recessive model of inheritance
BMI Body Mass Index, DBP diastolic blood pressure, FPG fasting plasma glucose, HDL high density lipoprotein cholesterol, LDL low density lipoprotein cholesterol, SBP systolic blood pressure, TC total cholesterol, TG Triglycerides, WC waist circumference
aIndicated a significant result
p-value*: p-values after Bonferroni correction
For the Bonferroni correction, p-values were multiplied by 3 (the number of SNPs in our study)
Calculations were performed using SNPassoc R package