Table 2.

Results of the multivariate analysis between ALB and the endpoints

N (death at 28 days)	794	757	581	482
Models	Non-adjusted HR (95% CI) P value	Adjusted I HR (95% CI) P value	Adjusted II HR (95% CI) P value	Fully adjusted HR (95% CI) P value
ALB (g/dL)	0.71 (0.61–0.82) < 0.0001	0.74 (0.63–0.88) 0.0004	0.75 (0.62–0.90) 0.0024	0.72 (0.58–0.90) 0.0039
ALB tertiles
Low (0.00–2.20 g/dl)	Ref	Ref	Ref	Ref
Middle (2.30–2.70 g/dl)	0.87 (0.71–1.08) 0.2042	0.86 (0.69–1.08) 0.1944	0.75 (0.57–0.98) 0.0332	0.81 (0.60–1.09) 0.1700
Middle (2.80–5.90 g/dl)	0.63 (0.51–0.79) < 0.0001	0.67 (0.53–0.85) 0.0008	0.64 (0.49–0.85) 0.0019	0.65 (0.47–0.89) 0.0069
P for trend	< 0.0001	0.0006	0.0022	0.0069
N (death at 90 days)	794	790	731	482
Models	Non-adjusted HR (95% CI) P value	Adjusted I HR (95% CI) P value	Adjusted II HR (95% CI) P value	Fully adjusted HR (95% CI) P value
ALB (g/dL)	0.70 (0.61–0.80) < 0.0001	0.75 (0.65–0.87) 0.0001	0.73 (0.63–0.86) < 0.0001	0.68 (0.55–0.85) 0.0005
ALB tertiles
low	Ref	Ref	Ref	Ref
middle	0.83 (0.68–1.02) 0.0713	0.83 (0.68–1.02) 0.0762	0.81 (0.65–1.00) 0.0547	0.72 (0.55–0.96) 0.0253
high	0.62 (0.50–0.76) < 0.0001	0.67 (0.54–0.82) 0.0002	0.63 (0.50–0.79) < 0.0001	0.60 (0.45–0.80) 0.0005
P for trend	< 0.0001	0.0001	< 0.0001	0.0006

Non-adjusted model adjusted for: None

Adjusted I model (death at 28 days) adjusted for: age, sex, P, BUN, Cr, UO, SOFA score, and Indications for CRRT

Adjusted I model (death at 90 days) adjusted for: age, sex, BUN, Cr, and SOFA scores

Adjusted II model (death at 28 days) adjusted for: age, sex, K, HCO3, P, aCCI, BMI, SBP, DBP, MAP, MV, WBC, HGB, BUN, Cr, CRP, UO, APACHE-II score, SOFA score, Indications for CRRT, CRRT dose, and AKIN

Adjusted II model (death at 90 days) adjusted for: age, sex, K, HCO3, P, aCCI, BMI, SBP, DBP, MAP, MV, WBC, HGB, BUN, Cr, GFR, UO, APACHE-II score, SOFA score, Indications for CRRT, CRRT dose, and AKIN

Fully adjusted model adjusted for: all variables except ALB and the endpoints