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. 2022 Apr;192(4):642–652. doi: 10.1016/j.ajpath.2022.01.007

Table 2.

Summary of Pertinent Patient Metadata for 20,196 Unique Patients Infected with Omicron or Delta Variant

Variable Omicron variant Delta variant Total Statistical analysis
Patients with data 4468 (22.1) 15,728 (77.9) 20,196
Patient characteristics
 Median age, years 44.3 48.3 47.6 P < 0.0001
(U-test)
 Female 2584 (57.8) 8123 (51.6) 10,707 (53.0) P < 0.0001
(Fisher exact test)
 Male 1884 (42.2) 7605 (48.4) 9489 (47.0)
Race or ethnicity
 White 1627 (36.4) 6903 (43.9) 8530 (42.2) P < 0.0001
2 test)
 Hispanic or Latino 992 (22.2) 4179 (26.6) 5171 (25.6)
 Black 1376 (30.8) 3450 (21.9) 4826 (23.9)
 Asian 203 (4.5) 531 (3.4) 734 (3.6)
 Other 29 (0.6) 112 (0.7) 141 (0.7)
 Unavailable 241 (5.4) 553 (3.5) 794 (3.9)
BMI
 Median BMI, kg/m2 29.0 29.6 29.4 P < 0.0001
(U-test)
Admission data
 Admitted 884 (19.8) 6779 (43.1) 7663 (37.9) P < 0.0001
(Fisher exact test)
Odds ratio: 0.326 (95% CI, 0.301–0.353)
 Not admitted 3584 (80.2) 8949 (56.9) 12,533 (62.1)
 Median LOS (discharged patients only), days 3.2 5.4 5.2 P < 0.0001
(U-test)
Max respiratory support
 ECMO 1 (0.1) 19 (0.3) 20 (0.3) P < 0.0001
2 test)
 Mechanical ventilation 49 (5.5) 727 (10.7) 776 (10.1)
 Noninvasive ventilation 63 (7.1) 641 (9.5) 704 (9.2)
 High-flow oxygen 72 (8.1) 1796 (26.5) 1868 (24.4)
 Low-flow oxygen 314 (35.5) 2290 (33.8) 2604 (34.0)
 Room air 385 (43.6) 1306 (19.3) 1691 (22.1)
Mortality
 Alive 4430 (99.1) 14,889 (94.7) 19,319 (95.7) P < 0.0001
(Fisher exact test)
Odds ratio: 0.152 (95% CI, 0.110–0.211)
 Deceased 38 (0.9) 839 (5.3) 877 (4.3)
Median PCR CT
 Abbott Alinity 20.8
(n = 1961)
21.5
(n = 5122)
n = 7083 P < 0.0001
(U-test)
 Hologic Panther 22.7
(n = 476)
22.6
(n = 1298)
n = 1774 P = 0.1606
(U-test)
Vaccine
 No vaccine 1815 (40.6) 11,415 (72.6) 13,230 (65.5) P < 0.0001
2 test)
 >7 Days past first vaccine 156 (3.5) 494 (3.1) 650 (3.2)
 >14 Days past second vaccine 1786 (40.0) 3679 (23.4) 5465 (27.1)
 >14 Days past third vaccine 711 (15.9) 140 (0.9) 851 (4.2)

Data are given as number (percentage) of patients, unless otherwise indicated.

BMI, body mass index; ECMO, extracorporeal membrane oxygenation; LOS, length of stay; Max, maximum.