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. 2022 Jan 18;23(3):226. doi: 10.3892/etm.2022.11150

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Expression levels of inflammation and oxidative-reduction related mRNA in heart tissue of mice using reverse transcription-quantitative PCR. (A) iNOS, (B) TNF-α, (C) IL-1, (D) IL-6, (E) IL-10 and (F) COX-2 in mouse heart tissues. Data are presented as the mean ± SD. Each experiment was repeated three times independently. ^*P<0.05 vs. NC group; ^#P<0.05 vs. OT group. DHE, dehydrocostus lactone; TXNIP, thioredoxin-interacting protein; NC, negative control; OT, DHE treatment group; OI, DHE treatment combined with TXNIP inhibition group; OH, DHE treatment combined with TXNIP overexpression group; iNOS, inducible nitric oxide synthase; COX-2, cyclooxygenase-2.