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. 2022 Jan 17;23(3):222. doi: 10.3892/etm.2022.11146

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Metformin can improve subchondral bone remodelling in a destabilization of the medial meniscus model. (A) Representative micro-CT images. Osteophyte and cartilage degeneration are marked by red arrows. Scale bar=2,000 µm. (B) Micro-CT two-dimensional scan of tibial subchondral bone. Scale bar=2,000 µm. (C) Micro-CT two-dimensional reconstructions of tibial subchondral bone. Scale bar=2,000 µm. Subchondral bone loss in the tibia is highlighted using a blue box. Increases in bone mass and bone sclerosis are highlighted using a yellow box. Quantification of bone morphological parameters (D) BV/TV, (E) Tb.Sp and (F) BMD. One-way ANOVA followed by Tukey's multiple comparison test was used to compare data among groups after testing the data for homogeneity of variance. ^*P<0.05; ^**P<0.01 and ^***P<0.001; ^#P<0.05; ^##P<0.01. BV/TV, bone volume fraction; Tb.Sp, trabecular separation; BMD, bone mineral density.