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Metformin can decrease chondrocyte pyroptosis in a destabilization of the medial meniscus model at gene level. Relative expression levels of (A) NLRP3, (B) caspase-1, (C) GSDMD and (D) IL-1β mRNA. One-way ANOVA followed by Tukey's multiple comparison test was used to compare data among groups after testing the data for homogeneity of variance. *P<0.05 and ***P<0.001; #P<0.05; ##P<0.01; ###P<0.001. NLRP3, NOD-like receptor protein 3; GSDMD, gasdermin D.
