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. 2022 Feb 2;13:49. doi: 10.1186/s13287-022-02724-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MSC/HA transplantation activated the PI3K-AKT pathway and increased follicle numbers in POI mouse model. a Western blot showing the activation of the PI3K-AKT pathway in the control, VCD, VCD + HA, and VCD + MSC/HA groups 4 days after transplantation. b Immunostaining showing the expression of DDX4 in ovaries 1 week after transplantation in the four groups. The yellow arrows indicate primordial follicles. Scale bars = 50 μm. c H&E staining of ovaries from the four groups at 10 weeks after transplantation. Scale bars = 100 μm. d Numbers of total follicles and e follicles at various stages were counted at 10 weeks after transplantation and compared with VCD group (n = 8 for each group). *P < 0.05, **P < 0.01. f Western blot showing the expression of germ cell markers MSY2 and SOHLH1 in ovaries from the four groups at 10 weeks after transplantation