Skip to main content
. 2022 Feb 2;13:49. doi: 10.1186/s13287-022-02724-3

Fig. 5.

Fig. 5

HA reinforced the paracrine ability of UC-MSCs to further activate the PI3K-AKT pathway and promote follicle survival. a Scatter diagram showing the differentially expressed proteins between MSC-CM and HA/MSC-CM according to the 440-cytokine array. b KEGG pathway analysis showing many differentially expressed proteins related to the PI3K-AKT signaling pathway. c The levels of HGF, VEGF, SCF, and EGF were measured by ELISA in MSC-CM and HA/MSC-CM (n = 3). *P < 0.05. d Western blot showing the activation of the PI3K-AKT pathway by MSC-CM and HA/MSC-CM. e Immunostaining showing the expressions of DDX4 in the ovaries in the four groups after culturing for 8 days. Scale bars = 50 μm