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. 2022 Feb 2;13:49. doi: 10.1186/s13287-022-02724-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MSC/HA transplantation mitigated age-related fertility impairment in mice. a Western blot showing the expression of p-AKT and p-rpS6 in the ovaries of young, aged, and aged + MSC/HA mice 4 days after transplantation. b Western blot and c H&E staining showing germ cell marker DDX4 expression and follicle preservation at 8 weeks after transplantation in the three groups. Scale bars = 200 μm. d The numbers of total follicles and e follicles at various stages were counted and compared in the three groups 8 weeks after transplantation (n = 5 for each group). *P < 0.05. PrF, primordial follicle; PF, primary follicle; SF, secondary follicle; AF, antral follicle. f, g Comparison of the average number of litters and number of pups per litter between aged mice and MSC/HA-treated aged mice (n = 7 or 8 for each group). *P < 0.05