Table 3.
Summary of reported BA/TA for pristine Ti64 scaffolds in the reviewed studies
| Author, date | Animal and bone defect | Group | BA/TA (%) | |||
|---|---|---|---|---|---|---|
| 4–6 weeks | 8–10 weeks | 12–14 weeks | 24–26 weeks | |||
| Arabnejad et al. 2016 [30] | Beagle dog, femur | Tetrahedron cell | 28.6 ± 11.6 | 41.3 ± 4.3 | / | / |
| Octet truss cell | 35.5 ± 1.9 | 56.9 ± 4. | ||||
| Chen et al. 2019 [31] | Beagle dog, tibia | / | 11.9 ± 2.2 | / | 15.9 ± 4.9 | / |
| Guo et al. 2020 [36] | Rabbit, f-epi | / | 11.6 ± 1.9 | 12.2 ± 2.0 | 24.1 ± 3.0 | / |
| Guo et al. 2018 [22] | Rabbit, f-epi | / | 13.2 ± 2.7 | 35.6 ± 2.7 | 55.9 ± 2.0 | / |
| Han et al. 2016 [37] | Rabbit, f-epi | Pore size 600 μm | 2.3 ± 0.4 | / | 3.5 ± 0.5 | / |
| Pore size 800 μm | 1.5 ± 0.1 | / | 2.4 ± 0.4 | / | ||
| Hara et al. 2016 [16] | Rabbit, femur | Pore size 500 μm | 34.9 ± 6.8 | / | 50.1 ± 8.3 | / |
| Pore size 640 μm | 37.0 ± 5.0 | / | 50.9 ± 6.7 | / | ||
| Pore size 800 μm | 27.2 ± 7.2 | / | 51.6 ± 6.4 | / | ||
| Pore size 1000 μm | 34.7 ± 8.4 | / | 35.1 ± 2.7 | / | ||
| Li et al. 2015 [41] | Rabbit, f-epi | / | 5.8 ± 2.2 | / | 12.2 ± 2.2 | / |
| Lv et al. 2015 [45] | Rabbit, f-epi | / | 7.8 ± 2.8 | / | / | / |
| Palmquist et al. 2017 [50] | Sheep, femur and tibia | Scaffold in femur | / | / | / |
Central: 26.5 ± 9.2 Peripheral: 57.2 ± 10.9 |
| Scaffold in tibia | / | / | / |
Central: 45.6 ± 19.5 Peripheral: 8.0 ± 10.4 |
||
| Palmquist et al. 2017 [51] | Sheep, f-epi | / | / | / | / | 44.7 ± 4.4 |
| Ragone et al. 2020 [26] | Sheep, femur and tibia | / |
Cortical: 75.0 ± 13.5 Cancellous: 27.0 ± 15.0 |
Cortical: 82.0 ± 5.0 Cancellous: 36.0 ± 10.5 |
Cortical: 82.0 ± 9.0 Cancellous: 51.0 ± 14.0 |
/ |
| Shah et al. 2016 [54] | Sheep, f-epi | / | / | / | / |
Central: 32.9 ± 4.8 Peripheral: 60.0 ± 4.6 |
| Song et al. 2019 [55] | Rabbit, femur | / | / | / | 6.8 ± 2.9 | 35.6 ± 5.3 |
| Tanzer et al. 2019 [19] | Beagle dog, femur | / | 41.5 ± 8.2 | / | 64.4 ± 2.8 | / |
| Tsai et al. 2019 [56] | Rabbit, femur | / | 2.5 ± 0.8 | / | / | / |
| Wang et al. 2018 [27] | Rabbit, femur | Diamond cell (r) | 34.0 ± 5.9 | 36.3 ± 1.0 | / | / |
| Diamond cell (ir) | 33.7 ± 5.0 | 36.8 ± 2.3 | / | / | ||
| Diamond cell (g) | 30.2 ± 3.3 | 32.3 ± 4.9 | / | / | ||
| Tetrahedron cell | 20.5 ± 3.0 | 24.3 ± 1.9 | / | / | ||
| Xiu et al. 2017 [60] | Rabbit, f-epi | / | / | 8.2 ± 2.3 | / | / |
| Xiu et al. 2017 [61] | Rabbit, f-epi | / | / | 10.8 ± 3.4 | / | / |
| Yu et al. 2020 [28] | Rabbit, femur | / | 46.3 ± 13.7 | 59.3 ± 8.1 | / | / |
*F-epi: femoral epiphysis; r: regularly distributed pores; ir: irregularly distributed pores; g: gradient distributed pores
*The data are all represented as means ± standard deviations, and reserved for one decimal point